PrecisionOnco 2027 • San Francisco, CA

Scientific Program & Curriculum Blueprint

Two-day multi-disciplinary symposium featuring plenary keynotes, concurrent scientific breakout tracks, moderated poster defenses, and translational case debates. Timings are displayed in Pacific Daylight Time (PDT / UTC-7).

14.5 Hours Total Contact Hours
12.0 Hours Didactic Lectures & Panels
2.5 Hours Moderated Poster Defense
4 Parallel Tracks Translational Breadth
Curriculum Taxonomy: Plenary / Joint Track A: Multi-Omics & Neoantigens Track B: Cell & Gene Therapies Track C: Liquid Biopsy & MRD Track D: Resistance & Combinations
Delegate Check-In & Credential Collection — Grand Foyer Secretariat Desk
07:30 – 08:30 PDT
08:30 – 10:00 PDT (90 Min) 1.5 Contact Hrs
Opening Joint Plenary Auditorium A (Main Hall)

The Next Decade of Precision Oncology: Converging Multi-Omics and Cellular Engineering

Opening governance remarks by the Scientific Chairs followed by two keynote addresses setting the benchmark for institutional next-generation sequencing adoption, computational neoepitope discovery, and systemic barrier removal in community clinical trial networks.

08:30 – 08:45
Secretariat & Scientific Chairs Opening Charter Colloquium Co-Chairs & Scientific Advisory Secretariat
08:45 – 09:25
Keynote 1: High-Resolution Spatial Biology in Refractory Tumor Microenvironments Invited Clinical Oncologist / Translational Laboratory Director
09:25 – 10:00
Keynote 2: Translating Single-Cell Sequencing Signatures into Frontline Therapeutic Selection Academic Cancer Center Faculty Chair
Morning Intermission & Exhibition Viewing — Networking Corridor & Commercial Booths
10:00 – 10:30 PDT
10:30 – 12:30 PDT (120 Min) 2.0 Contact Hrs
Track A • Proffered Papers Auditorium A

Genomic Drivers, Neoepitope Identification & Spatial Transcriptomics

Peer-reviewed proffered papers covering deep whole-exome sequencing, computational epitope mapping algorithms, and spatial transcriptomic dissection of solid tumor margins.

10:30 – 11:00
Invited Talk: Computational Pipelines for Personalized Peptide Vaccine Design Translational Bioinformatics Lead
11:00 – 11:30
Oral Proffered Paper 1: Spatial Multi-Omic Profiling in Platinum-Refractory Ovarian Carcinoma Selected Contributing Author (Peer-Reviewed Abstract)
11:30 – 12:00
Oral Proffered Paper 2: Epigenetic Biomarkers of Immunotherapy Non-Responsiveness Selected Contributing Author (Peer-Reviewed Abstract)
12:00 – 12:30
Clinical Panel & Open Floor Discussion: Integrating NGS into Frontline Hospital Formularies Moderated by Track A Committee Chairs
Seated Colleague Luncheon & Editorial Roundtable — Grand Banqueting Hall
12:30 – 13:45 PDT
13:45 – 15:00 PDT (75 Min) 1.25 Contact Hrs
Poster Defense Forum Poster Pavilion (Boards 01–60)

Moderated Poster Defense Session I: Molecular Targets & Diagnostics

Designated poster authors defend empirical findings before visiting faculty review panels. Attendance is tracked for accredited presenter defense contact hours. Includes light refreshments.

15:00 – 17:00 PDT (120 Min) 2.0 Contact Hrs
Track B • Proffered Papers Auditorium A

Next-Gen Cellular Immunotherapies: CAR-T, TCR-T & NK Cell Engineering

Investigating allogeneic gene editing platforms, dual-targeting chimeric antigen receptors, and clinical overcoming of immunosuppressive solid tumor microenvironments.

15:00 – 15:35
Invited Masterclass: Overcoming Exhaustion in CAR-T Cells via Multiplex CRISPR Knockouts Cellular Immunotherapy Laboratory Chair
15:35 – 16:05
Oral Proffered Paper 3: Off-the-Shelf Allogeneic NK Cells for Solid Tumors Selected Contributing Author (Peer-Reviewed Abstract)
16:05 – 16:35
Oral Proffered Paper 4: Phase I Safety Trial of Dual CD19/CD22 Targeting Constructs Selected Contributing Author (Peer-Reviewed Abstract)
16:35 – 17:00
Clinical Panel: Managing Cytokine Release Syndrome (CRS) & ICANS in Community Centers Clinical Hematology/Oncology Panelists
Day 1 Adjournment & Welcome Colleague Reception — Terrace Lounge
17:00 – 18:30 PDT
Morning Faculty Coffee & Registration Verification — Grand Foyer
08:00 – 08:30 PDT
08:30 – 10:15 PDT (105 Min) 1.75 Contact Hrs
Plenary Symposium Auditorium A

Liquid Biopsy, Minimal Residual Disease (MRD) & Longitudinal Monitoring

Circulating tumor DNA (ctDNA) dynamics, methylation profiling, fragmentomics, and clinical validity thresholds in early cancer detection and post-resection surveillance.

08:30 – 09:10
State-of-the-Art: ctDNA Dynamics as Surrogates for Progression-Free Survival Molecular Diagnostics Keynote Speaker
09:10 – 09:40
Oral Proffered Paper 5: Whole-Genome Fragmentomics for Multi-Cancer Early Detection Selected Contributing Author (Peer-Reviewed Abstract)
09:40 – 10:15
Oral Proffered Paper 6: Interventional MRD Clearance Trials in Colorectal Cancer Selected Contributing Author (Peer-Reviewed Abstract)
Coffee Intermission & Poster Viewing — Networking Corridor
10:15 – 10:45 PDT
10:45 – 12:45 PDT (120 Min) 2.0 Contact Hrs
Track D • Proffered Papers Auditorium A

Mechanisms of Targeted Resistance & Rationale for Combination Regimens

Secondary kinase mutations, bypass signaling activation, antibody-drug conjugate (ADC) internalization kinetics, and rational synergistic synthetic lethal combinations.

10:45 – 11:20
Invited Talk: Next-Generation KRAS G12C/D/V Inhibitors and Resistance Topography Thoracic Oncology Research Chair
11:20 – 11:50
Oral Proffered Paper 7: Dual Pathway Inhibition in MET-Amplified NSCLC Selected Contributing Author (Peer-Reviewed Abstract)
11:50 – 12:20
Oral Proffered Paper 8: Optimizing Payload Delivery Mechanisms in HER2-Low Breast Cancers Selected Contributing Author (Peer-Reviewed Abstract)
12:20 – 12:45
Clinical Panel: Sequencing Checkpoint Blockade with Next-Gen ADC Therapeutics Medical Oncology Discussion Panel
Seated Colleague Luncheon & Mentorship Network — Grand Banqueting Hall
12:45 – 13:45 PDT
13:45 – 15:00 PDT (75 Min) 1.25 Contact Hrs
Poster Defense Forum Poster Pavilion (Boards 61–120)

Moderated Poster Defense Session II: Clinical Trials & Translational Regimens

Moderated defense focusing on clinical pharmacology, investigator-initiated combination studies, and digital pathology algorithms.

15:00 – 16:45 PDT (105 Min) 1.75 Contact Hrs
Closing Plenary & Awards Auditorium A

Late-Breaking Clinical Trial Evidence & Secretariat Adjournment

High-impact late-breaking oral presentations, peer-review investigator awards, announcement of the 2028 assembly venue, and distribution of verified contact hour certificates.

15:00 – 15:45
Late-Breaking Proffered Oral Paper: Phase II Multi-Center Combination Trial Outcomes Principal Trial Investigator
15:45 – 16:15
Young Investigator & Best Poster Awards Presentation Scientific Program Committee Review Board
16:15 – 16:45
Secretariat Valedictory Address & Certificate Issuance Procedure Scientific Co-Chairs & Catalyst Colloquia Secretariat
Formal Assembly Adjournment & Certificate Dispatch — Digital Verification Desk
16:45 PDT
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